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Elecsys® PIVKA-II

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Elecsys® PIVKA-II 

Elecsys® PIVKA-II is an immunoassay for the quantitative measurement of protein induced by vitamin K absence or antagonist-II (PIVKA‑II) in human serum and plasma. The assay is used as an aid in the diagnosis of hepatocellular carcinoma (HCC). The results must be interpreted in conjunction with other methods in accordance with standard clinical management guidelines

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Only 63% Sensitivity

of Ultrasound + AFP
in detecting early stage HCC

37%
will be missed

 

◆ Poor performance in patients with fibrotic changes and fatty infiltration of the liver
◆ Difficult to perform in obese patients
◆ Difficult to detect small lesions (< 2cm)
◆ Limited capacity in public hospitals and rural settings
◆ Operator variability

 

 

AFP is not specific for HCC. It can be elevated (false positive) in the following conditions:
◆ Cirrhosis
◆ Active hepatitis
◆ Other types of tumours
AFP can be normal (false negative) in the following conditions:
◆ Certain HCC patients have normal AFP throughout the entire disease course
◆ Small size HCC (tumour < 2 cm)

The combination of PIVKA-II and AFP has markedly better sensitivity for detecting HCC vs AFP alone

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